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ダウンロード数 : ?
ID 106365
著者
カシワギ, マサユキ Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
石上, 安希子 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School KAKEN研究者をさがす
ハラ, ケンジ Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
マツスエ, アヤ Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
Waters, Brian Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
タカヤマ, ミオ Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
徳永, 逸夫 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
西村, 明儒 Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
クボ, シンイチ Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
キーワード
coma blister
sweat gland degeneration
apoptosis
intoxication
forensic autopsy cases
資料タイプ
学術雑誌論文
抄録
The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
3-4
開始ページ
256
終了ページ
261
並び順
256
発行日
2013-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系