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ID 110685
著者
石上, 安希子 Department of Legal Medicine, The University of Tokushima School of Medicine KAKEN研究者をさがす
久保, 真一 Department of Legal Medicine, The University of Tokushima School of Medicine
後藤田, 貴子 Department of Legal Medicine, The University of Tokushima School of Medicine
徳永, 逸夫 Department of Legal Medicine, The University of Tokushima School of Medicine
キーワード
methamphetamine
kidney
myoglobin
the 70 kDa heat shock protein
immunohistochemistry
資料タイプ
学術雑誌論文
抄録
Forensic autopsy cases detecting methamphetamine (MA) are usually diagnosed according to its toxicological concentration. It has been reported that the lethal blood concentration of MA is 4.48 μg/ml (3.0μmol/dl). We autopsied two MA-detected cadavers, and immunohistochemical staining was performed on the skeletal muscle with an anti-myoglobin antibody, and on the kidney with an anti-the 70 kDa heat shock protein(HSP70) antibody. One case showed a high rectal temperature (40℃). The toxicological examination revealed 0.75μg/ml of MA in the blood, and 16.8 μg/ml in the urine. Myoglobin was negative and HSP70 was positive in the kidney immunohistochemically. From the toxicological and immunohistochemical findings, it was considered that the subject died of hyperthermia and acidosis caused by muscular hyperactivity. In another case, the autopsy revealed highly congested lungs, with dark-red bloody fluid and foam in the trachea and bronchus. MA (17.0 μg/ml) was detected in the blood. HSP70 was negative and myoglobin was positive immunohistochemically. It was thought that the subject died of acute MA intoxication based on the high MA concentration, although rhabdomyolysis was suspected. It is suggested that myoglobin and HSP70 immunostaining are useful to diagnose MA poisoning.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
112
終了ページ
116
並び順
112
発行日
2003
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系