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ID 109959
タイトル別表記
骨粗鬆症病態下での骨折創傷治癒に対する副甲状腺ホルモンと低出力超音波の影響
PTH and LIPUS on Osteoporotic Fracture Healing
著者
マンスル, カリマ クルニア 徳島大学大学院口腔科学教育部(口腔科学専攻)
前田, 有一 Tokushima University
佐藤, 南 Tokushima University
キーワード
Low-intensity pulsed ultrasound
Parathyroid hormone
Osteoporotic fracture
Bone healing
Mechanical stimulation
資料タイプ
学位論文
抄録
Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with PTH (1–34) and LIPUS on fracture healing in ovariectomized (OVX) rats. Thirty-two, 12-week-old female Sprague–Dawley rats were OVX to induce osteoporosis. After 12 weeks, the rats underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n = 8 for each): control group as placebo, PTH group, LIPUS group, and combined group. PTH group had PTH administration at a dose of 30 lg/kg/day for 3 days/week for 6 weeks. LIPUS group received ultrasound 5 days/week for 20 min/day for 6 weeks and combined group had both PTH administration and LIPUS exposure for 6 weeks. Fracture healing was observed weekly by anteroposterior radiography and micro-CT. Five weeks after the fracture, the tibia were harvested to permit histological assessments and at week 6, for mechanical property of the fracture callus. Micro-CT showed that the PTH and combined groups exhibited significantly higher BMD and trabecular bone integrity than control group at weeks 4–6. Radiography, fracture healing score and mean callus area indicated that the combined group revealed better healing processes than the individual groups. Mechanically, bending moment to failure was significantly higher in LIPUS, PTH and combined groups than in control group. These data suggest that the combined treatment of PTH and LIPUS have been shown to accelerate fracture bone healing and enhance bone properties rather than single agent therapy, and may be considered as a treatment remedy for fracture healing in postmenopausal osteoporosis.
掲載誌名
Annals of Biomedical Engineering
ISSN
15739686
cat書誌ID
AA12104111
出版者
Springer nature
44
8
開始ページ
2480
終了ページ
2488
発行日
2016-01-21
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201611141025.pdf
審査要旨 : LID201611141026.pdf
論文本文 : k2976_fulltext.pdf
著者の申請により要約(2016-11-14公開)に替えて論文全文を公開(2019-06-05)
本論文は, 著者KARIMA Q. MANSJURの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© Biomedical Engineering Society 2016
This is a post-peer-review, pre-copyedit version of an article published in Annals of Biomedical Engineering.
The final authenticated version is available online at https://doi.org/10.1007/s10439-015-1533-y
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2976号
学位記番号
甲口第410号
学位授与年月日
2016-09-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
病院