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ID 110858
著者
サトウ, カズサ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
アライ, ヒデカズ Laboratory of Clinical Nutrition Management, Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, the University of Shizuoka
ミヤザワ, ユイ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
フカヤ, マキコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
上番増, 喬 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
コガネイ, メグミ Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
ササキ, ハジメ Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
サトウ, タダトシ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
山本, 浩範 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
竹谷, 豊 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Zucker fatty (fa/fa) rats
isomaltulose (palatinose)
sucrose
oleic acid
linoleic acid
pancreatic islet
資料タイプ
学術雑誌論文
抄録
We showed previously that 8-wk consumption of a diet containing palatinose (P, a slowly-absorbed sucrose analogue) and oleic acid (O) ameliorates but a diet containing sucrose (S) and linoleic acid (L) aggravates metabolic abnormalities in Zucker fatty (fa/fa) rats. In this study, we aimed to identify early changes in metabolism in rats induced by certain combinations of carbohydrates and fatty acids. Specifically, male Zucker fatty rats were fed an isocaloric diet containing various combinations of carbohydrates (P S) and fatty acids (O L). After 4 wk, no significant differences in bodyweight, visceral fat mass, plasma parameters (glucose, insulin, lipids, and adipokines), hepatic adiposity and gene expression, and adipose inflammation were observed between dietary groups. In contrast, pancreatic islets of palatinose-fed (PO and PL) rats were smaller and less fibrotic than sucrose-fed (SO and SL) rats. The abnormal_-cell distribution and sporadic staining of active caspase-3 common to islets of linoleic-acid-fed rats were not observed in oleic-acid-fed (PO and SO) rats. Accordingly, progressive_-cell loss was seen in SL rats, but not in PO rats. These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
3-4
開始ページ
183
終了ページ
195
並び順
183
発行日
2008-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系