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ID 115628
タイトル別表記
腸炎ビブリオは炎症を誘導し、Cystic Fibrosis Transmembrane Conductance Regulatorを介して下痢を誘導する
CFTR associated diarrhea in VP-infection
著者
射場, 仁美 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Kido, Junko Tokushima University
Hatayama, Sho Tokushima University
キーワード
Vibrio parahaemolyticus
CFTR
inflammation
diarrhea
COX-2
資料タイプ
学位論文
抄録
Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
68
1-2
開始ページ
59
終了ページ
70
並び順
59
発行日
2021-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hitomi Ibaの学位論文として提出され,学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3471号
学位記番号
甲栄第282号
学位授与年月日
2021-01-28
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系