| ID | 25668 |
| 著者 |
ハギ, アキフミ
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Hayashi, Hideki
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
岸, 和弘
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Lihong, Wang
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
蛯名, 洋介
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
徳島大学 教育研究者総覧
KAKEN研究者をさがす
|
| キーワード | fMLP
PAF
glucose transport
GLUT1
G-protein coupled receptor
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | The chemoattractants, fMLP and PAF, stimulate glucose uptake in phagocytes to obtain an energy source for host defense. Glucose uptake in phagocytes is mainly regulated via glucose transporter type1 (GLUT1). To examine molecular mechanisms of facilitated glucose uptake in response to fMLP or PAF, we established CHO cells stably expressing fMLP or PAF receptor with c-myc epitope tagged GLUT1 which could immunologically detect GLUT1 on the cell surface. In the CHO cells, both fMLP and PAF directly triggered GLUT1 translocation from the intracellular pool to the cell surface, and stimulated glucose uptake. Therefore, in phagocytes, we propose that fMLP and PAF also trigger GLUT1 translocation to stimulate glucose uptake as an energy source for host defense.
|
| 掲載誌名 |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| cat書誌ID | AA11166929
|
| 巻 | 47
|
| 号 | 1-2
|
| 開始ページ | 19
|
| 終了ページ | 28
|
| 並び順 | 19
|
| 発行日 | 2000
|
| 備考 | |
| EDB ID | |
| フルテキストファイル | |
| 言語 |
eng
|
| 部局 |
先端酵素学研究所
|
