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ID 115261
タイトル別表記
Control of Thymic Growth
著者
Cowan, Jennifer E. National Institutes of Health
Bhandoola, Avinash National Institutes of Health
キーワード
thymus
Myc
cyclin D1
growth
involution
aging
資料タイプ
学術雑誌論文
抄録
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.
掲載誌名
Frontiers in Immunology
ISSN
16643224
出版者
Frontiers Media S.A.
11
開始ページ
897
発行日
2020-05-12
権利情報
This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) ( https://creativecommons.org/licenses/by/4.0/ ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所