アクセス数 : ?
ダウンロード数 : ?
ID 114971
著者
Kikuta, Satomi Tohoku University|Japan Science and Technology Agency|Japan Society for the Promotion of Science
Nakamura, Yukiyo Tokushima University
Yamamura, Yukio Tokushima University
Tamura, Atsushi Tohoku University|Japan Science and Technology Agency|Northwestern University
Homma, Noriyasu Tohoku University
Yanagawa, Yuchio Japan Science and Technology Agency|Gunma University
Tamura, Hajime Tohoku University
小山内, 実 Tohoku University|Japan Science and Technology Agency
資料タイプ
学術雑誌論文
抄録
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
5
開始ページ
12800
発行日
2015-08-10
権利情報
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系