直近一年間の累計
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ID 115627
タイトル別表記
前立腺特異抗原スクリーニングにより発見された前立腺癌を有する日本人血液透析患者の長期的な転帰
PSA screening in hemodialysis patients
著者
横田, 成司 徳島大学大学院医科学教育部(医学専攻)
Nishitani, Masaaki Kawashima Hospital
Minakuchi, Jun Kawashima Hospital
キーワード
hemodialysis
prostate cancer
PSA
資料タイプ
学位論文
抄録
We investigated the long-term outcomes of the Japanese hemodialysis patients with prostate cancer detected by prostate-specific antigen (PSA) screening. Clinical data of 646 male hemodialysis patients aged 55 years or older who started yearly PSA testing in the period from January 1, 2004 to December 31, 2012 and were followed until December 31, 2017 were analyzed retrospectively. The median follow-up period was 10.4 years. Nineteen (2.9%) patients were diagnosed with prostate cancer, of whom one patient died of the disease. Androgen-deprivation therapy (ADT) was selected for primary prostate cancer treatment in 17 (89.5%) of these 19 patients. Of six prostate cancer patients who underwent primary ADT (PADT) and died of other causes, three died of infectious disease, each one died of cardiovascular disease, liver cancer, and chronic renal failure. No significant difference was observed in regard to overall survival between the prostate cancer patients with PADT and non-prostate cancer patients. Prognosis of hemodialysis patients who were diagnosed with prostate cancer during yearly PSA screening examination and mainly treated with ADT was favorable without increasing cardiovascular events. This result indicates that PSA screening may be useful for detection and management of prostate cancer even in hemodialysis patients.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
68
1-2
開始ページ
42
終了ページ
47
並び順
42
発行日
2021-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Narushi Yokotaの学位論文として提出され,学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3470号
学位記番号
甲医第1475号
学位授与年月日
2021-01-28
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系