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ID 111273
タイトル別表記
過剰なリン摂取は若年健常男性において血管内皮機能を障害する : 時間・用量試験
著者
西, 玉枝 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Ogawa, Mariko University of Tokushima
Ohya, Miho University of Tokushima
Nakanishi, Misaki University of Tokushima
Katsumoto, Misaki University of Tokushima
キーワード
phosphorus
endothelial dysfunction
flow-mediated vasodilation
hyperphosphatemia
chronic kidney disease
資料タイプ
学位論文
抄録
Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h, while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
167
終了ページ
172
並び順
167
発行日
2015-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201506051001.pdf
論文本文 : LID201509141001.pdf
本論文は,著者Tamae Nishiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2847号
学位記番号
甲栄第225号
学位授与年月日
2015-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系