直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 117924
著者
Nakagawa, Yusuke Tokushima University
Tada, Atsushi Tokushima University
Kojo, Kosuke International University of Health and Welfare Hospital|University of Tsukuba
Tsuchiya, Haruki International University of Health and Welfare Hospital
Kurobe, Masahiro International University of Health and Welfare Hospital
Uchida, Masahiro International University of Health and Welfare Hospital|Tsukuba Gakuen Hospital
Yamasaki, Kazumitsu International University of Health and Welfare Hospital|Tsukuba Gakuen Hospital
Iwamoto, Teruaki International University of Health and Welfare Hospital|Sanno Hospital
キーワード
Y chromosome
AZF
Non-obstructive azoospermia
Infertility
Japanese men
資料タイプ
学術雑誌論文
抄録
Deletion of the azoospermia factor c (AZFc), located on the long arm of the Y chromosome, is a cause of male infertility. The structure of the Y chromosome is diversified by the copy number of various genes, such as deleted in azoospermia (DAZ), basic protein Y2, chromodomain Y1, testis-specific transcript Y-linked 4, and Golgi autoantigen golgin subfamily a2 like Y, located in the AZF region. In this study, we investigated the deletion of each gene copy and analyzed its relationship with Japanese male infertility. Deletions of single nucleotide variants of each gene copy in 721 proven fertile men as controls, 139 patients with non-obstructive azoospermia (NOA), and 56 patients with oligozoospermia (OS) were analyzed via polymerase chain reaction-restriction fragment length polymorphism analysis. Their association with infertility was analyzed using logistic regression analysis adjusted for the Y-chromosome haplogroup, D1a2a. Deletions of DAZ/II in the r1 region and DAZ/V in the r1 and r2 regions showed significant associations with NOA (odds ratio [OR] = 4.15, 95% confidence interval [CI] = 1.18–14.6, P = 0.026; OR = 4.19, 95% CI = 1.19–14.7, P = 0.025, respectively). They did not show any association with OS. Partial deletion of the AZFc region affects spermatogenesis in Japanese male.
掲載誌名
Reproductive Biology
ISSN
1642431X
2300732X
cat書誌ID
AA12796059
出版者
Society for Biology of Reproduction|Institute of Animal Reproduction and Food Research of Polish Academy of Sciences|Elsevier
23
1
開始ページ
100728
発行日
2023-01-12
権利情報
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系