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ID 106005
著者
酒井, 徹 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
首藤, 恵泉 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
タキ, トモヨ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
イマムラ, ホナミ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
キオカ, ミク Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
中本, 晶子 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ミゾグチ, セイジ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
アマノ, ショウコ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
カワノ, ユカリ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
中本, 真理子 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
堤, 理恵 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
保坂, 利男 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
キーワード
cathepsin E
dendritic cells
MHC class II
NC/Nga mice
資料タイプ
学術雑誌論文
抄録
NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)- immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
59
1-2
開始ページ
95
終了ページ
101
並び順
95
発行日
2012-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系