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ID 115606
著者
Ikeda, Mayumi Tokushima University
異島, 優 Tokushima University|Monash University Malaysia 徳島大学 教育研究者総覧
Chuang, Victor T. G. Monash University Malaysia
Sakai, Maki Tokushima University
Osafune, Hiroki Tokushima University
Watanabe, Hiroshi Kumamoto University
Maruyama, Toru Kumamoto University
Otagiri, Masaki Sojo University
Akaike, Takaaki Tohoku University
キーワード
polysulfide
biological fluids
circadian rhythm
aging
資料タイプ
学術雑誌論文
抄録
Intracellular polysulfide could regulate the redox balance via its anti-oxidant activity. However, the existence of polysulfide in biological fluids still remains unknown. Recently, we developed a quantitative analytical method for polysulfide and discovered that polysulfide exists in plasma and responds to oxidative stress. In this study, we confirmed the presence of polysulfide in other biological fluids, such as semen and nasal discharge. The levels of polysulfide in these biological fluids from healthy volunteers (n = 9) with identical characteristics were compared. Additionally, the circadian rhythm of plasma polysulfide was also investigated. The polysulfide levels detected from nasal discharge and seminal fluid were approximately 400 and 600 μM, respectively. No correlation could be found between plasma polysulfide and the polysulfide levels of tear, saliva, and nasal discharge. On the other hand, seminal polysulfide was positively correlated with plasma polysulfide, and almost all polysulfide contained in semen was found in seminal fluid. Intriguingly, saliva and seminal polysulfide strongly correlated with salivary amylase and sperm activities, respectively. These results provide a foundation for scientific breakthroughs in various research areas like infertility and the digestive system process.
掲載誌名
Molecules
ISSN
14203049
出版者
MDPI
24
9
開始ページ
1689
発行日
2019-04-30
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系