アクセス数 : ?
ダウンロード数 : ?
ID 116049
タイトル別表記
肺癌患者におけるリンパ節転移の評価に関するdynamic PET/CTの有用性の前向き検討
Semiquantitative assessment of FDG uptake in primary tumours
著者
山中, 森晶 徳島大学大学院医科学教育部(医学専攻)
Kubo, Michiko Tokushima University
キーワード
fluorodeoxyglucose F18
PET-computed tomography
lung cancer
lymphatic metastasis
positron emission tomography computed tomography
資料タイプ
学位論文
抄録
Objective: To semiquantitatively estimate fluorine-18-fluorodeoxyglucose (FDG) uptake in primary lung cancer cells using dynamic and dual-time-point (DTP) positron emission tomography/computed tomography (PET/CT) to obtain a diagnostic index for lymph node (LN) metastasis.
Methods: Forty-five patients with lung cancer underwent dynamic and DTP PET/CT examinations. All primary lesions and LN metastases were evaluated pathologically. At each time phase, we assessed the maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of the primary tumours. We investigated the relationship between semiquantitative index and the presence of LN metastasis for each case and for all cases satisfying indications for segmentectomy. In cases with LN metastasis, we assessed the SUVmax of pathologically proven metastatic LNs and non-metastatic LNs in each dynamic phase for evaluating temporal change.
Results: Among 45 patients, 15 had 17 LN metastasis. SUVmax, MTV, and TLG of primary tumours at each time phase were significantly associated with LN metastasis (p < 0.05). In receiver operating characteristic analysis, dynamic second and third phases showed high diagnostic ability for LN metastasis. The temporal change in SUVmax in the dynamic phase between primary tumours and metastatic LNs were significantly different (p = 0.065). The temporal change in SUVmax was significantly lower in non-metastatic LNs than in primary tumours and metastatic LNs (p < 0.0001).
Conclusions: Semiquantitative assessment of FDG uptake in dynamic second and third phases and the assessment of temporal changes in SUVmax on dynamic PET/CT scans were important predictors in diagnosing LN metastasis.
掲載誌名
Nuclear Medicine Communications
ISSN
01433636
14735628
cat書誌ID
AA10624879
AA12542753
出版者
Wolters Kluwer Health, Inc.|British Nuclear Medicine Society
41
11
開始ページ
1189
終了ページ
1198
発行日
2020-11-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Moriaki Yamanakaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is a non-final version of an article published in final form in Yamanaka Moriaki, Shinya Takayoshi, Otomi Yoichi, Kubo Michiko, Arai Yuta, Toba Hiroaki, Bando Yoshimi, Otsuka Hideki, Harada Masafumi, Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer: a prospective study, Nuclear Medicine Communications Vol.41 Issue 11 p. 1189-1198
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3495号
学位記番号
甲医第1477号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系