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ID 109545
著者
オオニシ, リツコ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
瀬川, 博子 Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
オオモト, トモヨ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
ササキ, ショウヘイ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
ハナザキ, アイ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
モリ, アヤカ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
イクタ, カヨ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
フルタニ, ジュンヤ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
カワカミ, エリ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
タツミ, サワコ Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
濵田, 康弘 Department of Therapeutic Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮本, 賢一 Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
dietary phosphate
sensing
calcium
phosphate excretion
資料タイプ
学術雑誌論文
抄録
Dietary inorganic phosphate (Pi) is the most important factor in the regulation of renal Pi excretion. Recent studies suggest the presence of an enteric-renal signaling axis for dietary Pi as well as the existence of a mechanism by which the intestine detects changes in luminal Pi concentrations. The mechanisms of intestinal Pi sensing, however, are unknown. In the present study, we focused on Pi depletion signals and investigated the effects of dietary components on intestinal Pi sensing. After feeding rats experimental diets for 3 days, we investigated urinary Pi excretion and plasma biochemical parameters. Renal Pi excretion was suppressed in rats fed a low-Pi diet (0.02% Pi). Elimination of dietary calcium (Ca) completely blocked the suppression of Pi excretion, suggesting that the presence of Ca is essential for the Pi depletion signal. Furthermore, a minimum Ca content of more than 0.02% was necessary for the Pi depletion signal. Magnesium, lanthanum, and strontium, which are agonists of calcium sensing receptor, instead of Ca, reduced Pi excretion.Therefore, dietary Ca appears to be important for the Pi depletion-sensing mechanism in the gastrointestinal tract. In addition, the calcium sensing receptor may be involved in the Pi depletion signal.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
162
終了ページ
170
並び順
162
発行日
2014-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系