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ID 110455
タイトルヨミ
チュウスウ ゼンテイケイ ニオケル ヘイコウ ダイショウ ノ ブンシ キコウ
タイトル別表記
Molecular mechanisms of vestibular compensation in the central vestibular system
著者
キーワード
vestibular compensation
cerebellum
protein phosphatase
glutamate receptor
neural plasticity
資料タイプ
学術雑誌論文
抄録
The differential display method was applied to identify genes expression of which is upordown-regulated in the flocculus after unilateral labyrinthectomy (UL) in rats. TotalRNAs from sham operated flocculus and labyrinthectomized flocculus were isolated andamplified by PCR using arbitrary primer sets. PCR products the amounts of which weresignificantly higher or lower in samples from operated animals than those from controls,were cut out of the gel and sequenced. One of the higher expressed fragments showed100% nucleotide sequence identify to protein phosphatase 2A (PP2A) beta catalytic subunitmRNA. In animals with continuous floccular infusion of okadaic acid, a potent inhibitor ofPP 2 A, UL-induced spontaneous nystagmus (SN) lasted significantly longer. One of the lowerexpressed fragments showed 100% nucleotide sequence identify to glutamate receptor (GluR)delta-2 subunit mRNA. UL-induced SN in GluR delta-2 mutant mice was exacerbated at theinitial stage. All these findings suggest that up-regulation of PP2A beta and down regulateGluR delta-2 in flocculus after UL is involved in lesion-induced vestibular plasticity.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
56
4
開始ページ
132
終了ページ
135
並び順
132
発行日
2000-08-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系