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ID 119337
タイトル別表記
乳癌患者における化学療法の有害事象 : CTCAE、PRO-CTCAEおよびEORTC QLQ-C30を用いた検討
Adverse events of chemotherapy in breast cancer
著者
荒堀, 広美 徳島大学大学院保健科学研究科(保健学専攻)
キーワード
Breast cancer
CTCAE
PRO-CTCAE
EORTC QLQ-C30
Chemotherapy
資料タイプ
学位論文
抄録
Background : The Common Terminology Criteria for Adverse Events (CTCAE) is used as a tool to evaluate the adverse events (AE) of chemotherapy in cancer patients. Since CTCAE by medical providers underestimates AE more than patient-reported outcomes (PRO), the National Cancer Institute developed PRO-CTCAE. The present study investigated differences between symptoms detected using CTCAE by medical providers and PRO-CTCAE by breast cancer patients. Methods : Patients received chemotherapy comprising epirubicin and cyclophosphamide pre- or postoperatively. AE were evaluated using 4 questionnaires : PRO-CTCAE, CTCAE, the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire (EORTC-QLQ-30), and Hospital Anxiety and Depression Scale (HADS) after 1, 2, and 3 courses of chemotherapy. Results : Forty-two patients were registered. Regarding the recognition of psychological symptoms, such as fatigue, anxiety, and discouragement, and subjective symptoms, including heart palpitations and shortness of breath, PRO using PRO-CTCAE was significantly higher than medical provider-recognized outcomes using CTCAE. Concerning the recognition of regimen-specific symptoms, such as vomiting, nausea, and decreased appetite, medical provider-recognized outcomes were the same or higher than PRO. In QLQ-C30, the physical and role functions, fatigue and dyspnea significantly worsened after 2 and 3 courses of chemotherapy.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
71
1-2
開始ページ
82
終了ページ
91
並び順
82
発行日
2024-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiromi Arahoriの学位論文として提出され,学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3803号
学位記番号
甲保第66号
学位授与年月日
2024-03-22
学位名
博士(保健学)
学位授与機関
徳島大学
部局
医学系
病院