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ID 109692
タイトル別表記
花粉曝露室のスギ花粉曝露によりスギ花粉症患者に誘発された鼻粘膜ヒスタミンH1受容体mRNA発現亢進に対する抗ヒスタミン薬の影響
著者
中川, 英幸 徳島大学大学院医科学教育部(医学専攻)
Sakoda, Takema Rinku General Medical Center
Enomoto, Tadao NPO Japan Health Promotion Supporting Network
キーワード
histamine H1 receptor
antihistamines
allergic rhinitis
cedar pollinosis
environmental exposure unit
資料タイプ
学位論文
抄録
In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the upregulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders.
掲載誌名
Journal of Pharmacological Sciences
ISSN
13478613
cat書誌ID
AA11806667
AA12022662
出版者
Japanese Pharmacological Society|Elsevier
129
3
開始ページ
183
終了ページ
187
発行日
2015-10-30
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606071012.pdf
論文本文 : LID201606071013.pdf
本論文は,著者Hideyuki Nakagawaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
Copyright: © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2953号
学位記番号
甲医第1286号
学位授与年月日
2016-03-22
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系
薬学系