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ID 115585
著者
Sato, Hideo Tokushima University
Nakamura, Tenta Tokushima University
Hamada, Mai Tokushima University
Nagano, Shuji Tokushima University
Kameyama, Shuhei Tokushima University
Furue, Yui Kyoto Pharmaceutical University
Hayashi, Naoki Kyoto Pharmaceutical University
Kamoshida, Go Kyoto Pharmaceutical University
Oda, Masataka Kyoto Pharmaceutical University
キーワード
antibiotics
natural product
P. gingivalis
methicillin-resistant S. aureus
資料タイプ
学術雑誌論文
抄録
Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), and a Gram-negative bacterium, Porphyromonas gingivalis, were evaluated. The results showed that derivatives having an iodine atom on their aromatic ring instead of the prenyl moiety displayed better antimicrobial activity than eurotiumide A against MSSA and P. gingivalis. Moreover, we discovered that a derivative with an isopentyl side chain, which is a hydrogenated product of eurotiumide A, is the strongest antimicrobial agent against all three strains, including MRSA.
掲載誌名
Marine Drugs
ISSN
16603397
出版者
MDPI
18
2
開始ページ
92
発行日
2020-01-30
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系