Kimura, Yuki Tokushima University
Ohashi, Eisaku Tokushima University
Taniguchi, Takashi Tokushima University
Imagawa, Hiroshi Tokushima Bunri University
The first total syntheses of two 4,10-dihydroxy 8,12-guaianolides that were reported to be natural products, were achieved. Toward the syntheses of a collection of related guaianolides, the typical 5,7-fused system of 8,12-guaianolides was constructed by a ring expansion reaction of a hydroxylated coronafacic acid analog that can be practically synthesized and optically resolved. The total syntheses of these compounds revealed that the previously reported structures of both natural products were incorrect.
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.2c01215.
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