ID | 111454 |
著者 |
香西, 博之
Tokushima University
山下, 雄也
Tokushima University
Nishimura, Haruka
Tokushima University
近藤, 真代
Tokushima University
|
キーワード | interstitial pneumonia
anti-aminoacyl tRNA synthetase antibody syndrome
anti-PL-7antibody
rheumatoid arthritis
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資料タイプ |
学術雑誌論文
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抄録 | A 65-year-old female had been treated rheumatoid arthritis (RA), interstitial pneumonia (IP) and nephrotic syndrome with prednisolone and cyclosporine. She was emergently admitted to our hospital due to the worsening exertional dyspnea and severe hypoxemia. Chest computed tomography (CT) showed new diffuse ground-glass opacities (GGOs) with slight consolidations along with bronchovascular bundle were observed in addition to pre-existing reticular shadows in both lungs with lower lobe-predominance. An acute exacerbation (AE) of pre-existing IP triggered by an infection was suspected, and the treatment with antibiotics and corticosteroid pulse therapy improved her general condition and chest radiological findings. Because some auto-antibodies associated with acute/subacute onset IP have recently become available in clinic, we examined those including anti-aminoacyl tRNA synthetase (ARS) antibodies, and found that she was positive for anti-PL-7 antibody. We diagnosed her anti-synthetase syndrome (ASS) without symptom of myositis, and her IP was considered to be ASS-related. The careful consideration is necessary to precisely diagnose and treat the patients with RA-associated interstitial lung diseases as the several etiologies may be overlapped in the same patient.
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掲載誌名 |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
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cat書誌ID | AA11166929
AA12022913
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出版者 | Faculty of Medicine Tokushima University
|
巻 | 65
|
号 | 1-2
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開始ページ | 147
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終了ページ | 150
|
並び順 | 147
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発行日 | 2018-02
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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