ID | 112232 |
タイトル別表記 | ヤヌスキナーゼ阻害が体組成および糖代謝に与える影響
Effect of JAK inhibition on body composition
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著者 |
筑後, 桃子
徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Sebe, Mayu
Tokushima University
Iuchi, Marina
Tokushima University
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キーワード | Rheumatoid arthritis
Tofacitinib
Body composition
関節リウマチ
体組成
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資料タイプ |
学位論文
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抄録 | Tofacitinib is the first Janus Kinase (JAK) inhibitor to treat moderately to severely active RA. In this study, we investigated whether the effect of tofacitinib have any effects on body composition in mice and female patients with RA. Female C57BL/6 mice fed with a high-fat diet were treated with 30 mg/kg/day tofacitinib or vehicle for 70 days. Following treatment, trunk muscle, subcutaneous fat, and visceral fats were measured using X-ray computed tomography CT scan. Glucose tolerance and insulin sensitivity were assessed. In female RA patients treated with biological disease modified anti-rheumatic-drugs (biological DMARDs) or tofacitinib (n=4 per group), we also evaluated the body composition after 3 months from the start of treatment initiation using bioelectrical impedance analysis. Treatment with tofacitinib did not affect the body weight, and body composition in C57BL/6mice. It also did not affect glucose, and insulin tolerance in mice. In patients with RA, treatment with biological DMARDs did not affect the body composition whereas the muscle mass was unchanged after receiving tofacitinib and the fat mass was significantly increased.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA12022913
AA11166929
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出版者 | Faculty of Medicine Tokushima University
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巻 | 65
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号 | 3-4
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開始ページ | 166
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終了ページ | 170
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並び順 | 166
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発行日 | 2018-08
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Momoko Chikugoの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3148号
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学位記番号 | 甲栄第257号
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学位授与年月日 | 2018-03-23
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学位名 |
博士(栄養学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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