ID | 114399 |
著者 |
Minato, Masanori
Tokushima University
Murakami, Naoka
Harvard Medical School
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キーワード | nivolumab
onconephrology
immune-related adverse events (irAEs)
glomerular injury
IgA nephropathy
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資料タイプ |
学術雑誌論文
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抄録 | Immune checkpoint inhibitors (ICIs) are becoming a common and important cancer therapy. ICIs are associated with a unique category of side effects, termed immune-related adverse events (irAEs). We herein report the case of a 72-year-old man with postoperative recurrence of lung squamous cell carcinoma who was treated with nivolumab and who developed proteinuria and a worsening kidney function. A kidney biopsy revealed IgA nephropathy. After drug withdrawal, the proteinuria improved and the deterioration of the patient’s renal function was halted. Although renal irAEs are considered to be rare and glomerulonephritis is not typical presentation, physicians need to pay more attention to renal irAEs and glomerular injury.
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掲載誌名 |
Internal Medicine
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ISSN | 13497235
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出版者 | The Japanese Society of Internal Medicine
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巻 | 57
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号 | 9
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開始ページ | 1259
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終了ページ | 1263
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発行日 | 2018-05-01
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権利情報 | The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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言語 |
eng
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出版社版
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部局 |
病院
医学系
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