直近一年間の累計
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ID 116558
著者
Khan, Luqman Tohoku University
Sato, Katsumi Tohoku Rosai Hospital
Okuyama, Shinichi Home Doctors Okuyama
Kobayashi, Takeshi Nagoya University
Ohashi, Kazumasa Tohoku University
Takada, Kunio Tohoku University
Higashitani, Atsushi Tohoku University
Abiko, Kenji Tohoku University
キーワード
Cell differentiation
Cell proliferation
Fe
Mesenchymal stem cells
Myoblast
資料タイプ
学術雑誌論文
抄録
Metals and alloys are used widely in bone prosthetic materials, stents and dental tissue reconstructions. The most common materials are stainless steels and cobalt-chromium-nickel and titanium alloys. These alloys can be easily deformed but are hard to break. However, their affinity for cells and tissues is very low. In addition, they can sometimes provoke unexpected metal allergies. Iron is an abundant trace element essential for humans. However, excess amounts in particular of Fe2+ ions are toxic. We previously succeeded in obtaining 99.9996% ultra-high-purity iron (ABIKO iron). The chemical properties of ABIKO iron are completely different from that of conventional pure iron. For example, the reaction rate in hydrochloric acid is very slow and there is barely any corrosion. Here, we found that, in the absence of any type of coating, mammalian cells could easily attach to, and normally proliferate and differentiate on, ABIKO iron. On the other hand, cell densities and proliferation rate of the surfaces of plates made from Co–Cr–Mo or Ti–6Al–4V were significantly reduced. In addition, several stress and iron response genes, HSP70, SOD1, ATM and IRP2 did not change in the cells on ABIKO iron, while these genes were induced with exogenous application of FeSO4. Cells also secreted and fastened some organics on ABIKO iron. In vitro collagen binding assay showed that ABIKO iron binds higher amount of collagens. These findings highlight ABIKO iron as a novel biocompatible prosthetic material.
掲載誌名
Journal of the Mechanical Behavior of Biomedical Materials
ISSN
17516161
cat書誌ID
AA12344261
出版者
Elsevier
106
開始ページ
103744
発行日
2020-03-27
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系