Koyama, Hiroshi Tokushima University
牟礼, 英生 Tokushima University|Kurashiki Heisei Hospital KAKEN研究者をさがす
森垣, 龍馬 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮本, 亮介 Tokushima University 徳島大学 教育研究者総覧
三宅, 一央 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Matsuda, Taku Tokushima University
藤田, 浩司 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
和泉, 唯信 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
梶, 龍兒 Tokushima University|National Hospital Organization Utano Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
後藤, 惠 Tokushima University KAKEN研究者をさがす
髙木, 康志 Tokushima University 徳島大学 教育研究者総覧
deep brain stimulation
globus pallidus internus
Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% (p < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD.
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