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ID 114736
タイトル別表記
妊娠中の血清ビオチン濃度は胎児の成長と早産に関連する
Serum biotin level during pregnancy
著者
市原, 裕子 徳島大学大学院医科学教育部(医学専攻)
Fukui, Maika Tokushima University
Shono, Miki Tokushima University
キーワード
biotin
pregnancy
preterm birth
fetal growth restriction
small for gestational age
資料タイプ
学位論文
抄録
Background : Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Method : This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Results : Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusion : This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
67
1-2
開始ページ
170
終了ページ
173
並び順
170
発行日
2020-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yuko Ichiharaの学位論文として提出され, 学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3368号
学位記番号
甲医第1451号
学位授与年月日
2020-03-18
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系