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ID 113985
タイトル別表記
免疫組織化学法を用いた一側内耳破壊ラットの前庭代償の新しい評価法の開発
著者
松田, 和徳 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
Kitahara, Tadashi Nara Medical University
Ito, Taeko Nara Medical University
Fukushima, Munehisa Kansai Rosai Hospital
Uno, Atsuhiko Osaka General Medical Center
坂田, ひろみ Kanazawa Medical University KAKEN研究者をさがす
キーワード
Vestibular compensation
medial vestibular nucleus
spontaneous nystagmus
Fos
thioperamide
N-methyl-D-aspartate receptor
資料タイプ
学位論文
抄録
Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC.
Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC.
Materials and methods: MK801 (NMDA antagonist)-induced Fos-like immunoreactive (-LIR) neurons in contra-MVe, which had been suppressed by NMDA-mediated cerebellar inhibition in UL-rats was used as an index.
Results: The number of MK801-induced Fos-LIR neurons in contra-MVe gradually decreased to the same level as that of sham-operated rats 14 days after UL. Thioperamide moved the disappearance of the MK801-induced Fos-LIR neurons 2 days earlier. The number of MK801-induced Fos-LIR neurons in thioperamide-treated rats was significantly decreased, compared with that of vehicle-rats on days 7 and 12 after UL. But, thioperamide did not influence the decline of SN frequency in UL-rats.
Conclusion: There findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC.
掲載誌名
Acta Oto-Laryngologica
ISSN
00016489
16512251
cat書誌ID
AA0050923X
出版者
Taylor & Francis
139
6
開始ページ
505
終了ページ
510
発行日
2019-04-16
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kazunori Matsudaの学位論文として提出され,学位審査・授与の対象となっている。
This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica on 16/04/2019, available online: http://www.tandfonline.com/10.1080/00016489.2019.1599140
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3339号
学位記番号
甲医第1432号
学位授与年月日
2019-10-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系