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ID 115783
タイトル別表記
Pathophysiology and treatment of pulmonary circulation disorder and right heart failure : Paradigm shift in childhood heart disease
PA disorder and RV failure
著者
キーワード
pulmonary artery
potassium channel
pulmonary hypertension
optical coherence tomography
vasa vasorum
資料タイプ
学術雑誌論文
抄録
Potassium channels play diverse roles in regulating the behavior of pulmonary artery smooth muscle cells. The discovery of KCNK3(TASK1)as a new predisposing gene for pulmonary arterial hypertension(PAH)led to an update in the Nice Classification regarding the genetic origin of PAH. Decreased current via KCNA5(Kv1.5)plays a key role in determining pulmonary arterial tone and vascular remodeling. The transformation of smooth muscle cells causes ion channel switching, such as the loss of BKca(Kca1.1)and the gain of IKca(Kca3.1), in immature proliferative smooth muscle cells and also induces cell migration, proliferation, and apoptosis resistance.
We propose OCT as a useful tool in diagnosing pulmonary artery hypertension and may provide helpful information for the pulmonary arterial remodeling process, severity, therapeutic strategy, and prognosis in congenital heart disease.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
76
5-6
開始ページ
251
終了ページ
258
並び順
251
発行日
2020-12-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系