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ID 116981
タイトル別表記
マルチディレイ動脈スピンラベリング灌流法とボクセルベースの形態計測によって評価された注意欠陥/多動性障害の子供における脳の異常
著者
ゴンチグスレン, オユンダリ 徳島大学大学院医科学教育部(医学専攻)
Hisaoka, Sonoka Tokushima University
Higashi, Kohei Tokushima University
Sumida, Nami Tokushima University
伊藤, 弘道 Tokushima University|Naruto University of Education KAKEN研究者をさがす
Miyoshi, Mitsuharu GE Healthcare
キーワード
Attention-deficit/hyperactivity disorder
Cerebral blood flow
Magnetic resonance imaging
Pediatrics
資料タイプ
学位論文
抄録
Purpose:
To obtain an understanding of the correlation between hemodynamic differences and morphological changes as well as potential sex differences in children with ADHD using multi-delay pseudo-continuous arterial spin labeling (pCASL) imaging and voxel-based morphometry (VBM), especially given that previous findings are limited for girls.
Materials and methods:
We recruited 23 children with ADHD (mean age, 8.3 years; 19 boys; 4 girls) and 24 children without ADHD (mean age, 9.1 years; 13 boys; 11 girls) as controls. All participants underwent 3D multi-delay pCASL and T1-weighted imaging. The voxel-based statistical parameter mapping (SPM) method was used for group-wise comparisons.
Results:
Compared with controls, children with ADHD exhibited decreased regional cerebral blood flow (rCBF) and gray matter volume (GMV) in the left middle frontal gyrus and left postcentral gyrus. Analysis by sex revealed reduced rCBF and GMV in the left lingual gyrus and left inferior occipital gyrus in boys with ADHD versus controls and increased rCBF and GMV in the left superior frontal gyrus in girls with ADHD.
Conclusion:
Although our results are preliminary because of small sample sizes, several brain regions exhibit changes in both cerebral perfusion and GMV in the same direction in patients with ADHD, with boys with ADHD showing decreased activity and girls with ADHD displaying increased activity in the fronto-parietal cortices.
掲載誌名
Japanese Journal of Radiology
ISSN
18671071
1867108X
cat書誌ID
AA12375935
出版者
Japan Radiological Society|Springer Nature
発行日
2022-01-23
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Oyundari Gonchigsurenの学位論文として提出され,学位審査・授与の対象となっている。
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11604-021-01239-w
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3595号
学位記番号
甲医第1524号
学位授与年月日
2022-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院