直近一年間の累計
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ID 118598
著者
Asakuma, Hiroki Ezaki Glico Co., Ltd.
Horiuchi, Hiroko Ezaki Glico Co., Ltd.
Takii, Hiroshi Ezaki Glico Co., Ltd.
吉岡, 昌美 Tokushima Bunri University KAKEN研究者をさがす
キーワード
kiwifruit powder
microbiome
oral care tablet
tongue coating
資料タイプ
学術雑誌論文
抄録
Objectives: Tongue coating, a kind of biofilm formed on the tongue dorsum, is the cause of various clinical conditions, such as oral halitosis and periodontal diseases, because Fusobacterium nucleatum acts as a bridge between other oral bacteria and periodontopathogenic bacteria in biofilm formation. Our previous clinical study revealed that taking oral care tablets containing kiwifruit powder significantly reduced not only tongue‐coating index and volatile sulfur compounds but also total bacteria and F. nucleatum in tongue coating. In this study, we analyzed the microbiome of tongue coating samples obtained before and after oral care tablets intake to clarify whether this tablet is a useful tool for daily tongue care.
Methods: Thirty‐two healthy young adults were enrolled, and a crossover clinical trial was conducted. We instructed subjects to remove tongue coating by tongue brush for intervention I, to keep the oral care tablet containing kiwifruit powder on the tongue dorsum and to let it dissolve naturally for intervention II. Microbial DNA was isolated from the collected tongue coating samples in each subject, then 16S rRNA next‐generation sequencing, operational taxonomic unit clustering, and statistical analysis were performed.
Results: The microbiome analysis revealed that the oral care tablet in intervention II prompted a significant change in the tongue microbiota composition, a significant reduction in the relative abundance of Prevotella and Porphyromonas, and an increase in Firmicutes/Bacteroidetes ratio when compared to that in intervention I.
Conclusion: These results suggested that the oral care tablet might contribute to the improvement of the oral condition due to its good influence on the tongue coating microbiome.
掲載誌名
Clinical and Experimental Dental Research
ISSN
20574347
出版者
Wiley
8
3
開始ページ
721
終了ページ
728
発行日
2022-05-17
権利情報
This is an open access article under the terms of the Creative Commons Attribution License, ( https://creativecommons.org/licenses/by/4.0/ ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系