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ID 106041
著者
バンドウ, リョウタ Department of Clinical Support, the Tokushima University Hospital
生島, 仁史 Department of Radiation Therapy Technology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
川中, 崇 Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
工藤, 隆治 Department of Oral Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
佐々木, 幹治 Department of Clinical Support, the Tokushima University Hospital 徳島大学 教育研究者総覧
富永, 正英 Department of Radiation Therapy Technology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キシ, タロウ Department of Clinical Support, the Tokushima University Hospital
古谷, 俊介 Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
クボ, アキコ Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
タムラ, コウイチ Department of Otorhinolaryngology and Communicative Neuroscienece, Institute of Health Biosciences, the University of Tokushima Graduate School
キーワード
adaptive strategy
chemoradiation therapy
head and neck cancer
資料タイプ
学術雑誌論文
抄録
The treatment period over which radiation therapy is administered extends over several weeks. Since tumor shrinkage in response to radiation therapy and weight loss due to radiation-induced mucositis may impact on the dose distribution in both target and organ at risk in patients with head and neck cancer, the anatomical changes of tumor and neck volumes during this period should be taken into consideration. We investigated the anatomical changes that occurred in the target and normal structure of the neck during radiation therapy for pharyngeal cancer, and evaluated the necessity of an adaptive strategy. Ten patients with pharyngeal cancer who underwent radical chemoradiation therapy using 3-dimensional conformal radiation therapy RT (66-70 Gy in 33-35 fractions) between April 2009 and September 2010 were enrolled in the study. Patients underwent CT scans every week during their course of treatment. We analyzed the CT data in the radiation treatment planning system and measured changes of tumor, organ at risk, and neck volume. Gross tumor volume (GTV) was rapidly reduced by 28% of the original volume on average in the first 3 weeks. The right and left submandibular glands volume decreased to 70% and 63% of their initial volumes on average, respectively. The volume of the neck in the radiation fields decreased to 89% of its initial volume on average by the sixth week mainly caused by body weight loss due to acute radiation morbidity. Considerable anatomical change in the radiation filed that will affect dose distribution of the target and organ at risk was observed during radiation therapy for head and neck cancer.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
1-2
開始ページ
46
終了ページ
51
並び順
46
発行日
2013-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
歯学系
病院