| ID | 118579 |
| タイトル別表記 | Clozapine and Antipsychotic Monotherapy
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| 著者 |
Ochi, Shinichiro
Ehime University
Tagata, Hiromi
Toho University
Hasegawa, Naomi
National Center of Neurology and Psychiatry
Yasui-Furukori, Norio
Dokkyo Medical University
Kashiwagi, Hiroko
National Center of Neurology and Psychiatry
Kodaka, Fumitoshi
The Jikei University School of Medicine
Komatsu, Hiroshi
Tohoku University
Tsuboi, Takashi
Kyorin University
Tokutani, Akira
Hyogo College of Medicine
Ichihashi, Kayo
University of Tokyo
Onitsuka, Toshiaki
Kyushu University
Muraoka, Hiroyuki
Tokyo Women’s Medical University
Iida, Hitoshi
Fukuoka University
Ohi, Kazutaka
Gifu University
Atake, Kiyokazu
Nippon Telegraph and Telephone West Corporation
Kishimoto, Taishiro
Keio University
Hori, Hikaru
Fukuoka University
Takaesu, Yoshikazu
University of the Ryukyus
Takeshima, Masahiro
Akita University
Usami, Masahide
Kohnodai Hospital
Makinodan, Manabu
Nara Medical University
Hashimoto, Naoki
Hokkaido University
Fujimoto, Michiko
National Center of Neurology and Psychiatry|Osaka University
Furihata, Ryuji
Kyoto University
Nagasawa, Tatsuya
Kanazawa Medical University
Yamada, Hisashi
National Center of Neurology and Psychiatry|Hyogo College of Medicine
Matsumoto, Junya
National Center of Neurology and Psychiatry
Miura, Kenichiro
National Center of Neurology and Psychiatry
Kido, Mikio
Toyama City Hospital|University of Toyama
Hishimoto, Akitoyo
Yokohama City University
上野, 修一
Ehime University
Watanabe, Koichiro
Kyorin University
Inada, Ken
Kitasato University
Hashimoto, Ryota
National Center of Neurology and Psychiatry
|
| キーワード | Treatment-resistant schizophrenia
lithium
polypharmacy
guideline
EGUIDE
|
| 資料タイプ |
学術雑誌論文
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| 抄録 | Background: Although clozapine is effective for treatment-resistant schizophrenia (TRS), the rate of clozapine prescription is still low. Whereas antipsychotic monotherapy is recommended in clinical practice guidelines, the rate of antipsychotic polypharmacy is still high. There is little evidence on whether a clozapine prescription influences changes in the rate of monotherapy and polypharmacy, including antipsychotics and other psychotropics. We therefore hypothesized that the rate of antipsychotic monotherapy in patients with TRS who were prescribed clozapine would be higher than that in patients with schizophrenia who were not prescribed clozapine.
Methods: We assessed 8306 patients with schizophrenia nationwide from 178 institutions in Japan from 2016 to 2019. We analyzed the psychotropic prescription data at discharge in patients diagnosed with TRS and with no description of TRS (ND-TRS) based on the diagnosis listed in the discharge summary. Results: The rate of antipsychotic monotherapy in the TRS with clozapine group (91.3%) was significantly higher than that in the TRS without clozapine group (45.9%; P < 2.0 × 10−16) and the ND-TRS without clozapine group (54.7%; P < 2.0 × 10−16). The rate of antipsychotic monotherapy without any other concomitant psychotropics in the TRS with clozapine group (26.5%) was significantly higher than that in the TRS without clozapine group (12.6%; P = 1.1 × 10−6) and the ND-TRS without clozapine group (17.0%; P = 5.9 × 10−6). Conclusions: Clozapine prescription could be associated with a high rate of antipsychotic monotherapy. Patients will benefit from the correct diagnosis of TRS and thus from proper clozapine prescription. |
| 掲載誌名 |
International Journal of Neuropsychopharmacology
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| ISSN | 14611457
14695111
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| cat書誌ID | AA11545519
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| 出版者 | Oxford University Press
|
| 巻 | 25
|
| 号 | 10
|
| 開始ページ | 818
|
| 終了ページ | 826
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| 発行日 | 2022-06-20
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| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
医学系
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