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ID 115293
タイトル別表記
多重遅延3D動脈スピン標識法で測定した定量的脳血流の再現性および性別および月経周期の違いによる変動性について
Reproducibility of CBF using pCASL
著者
添木(大友), 真姫 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
Abe, Yumi Tokushima University
Miyoshi, Mitsuharu GE Healthcare
Kabasawa, Hiroyuki GE Healthcare
Takahashi, Yoshitake FUJIFILM Toyama Chemical
キーワード
neuroimaging
arterial spin labeling (ASL)
cerebral blood flow (CBF)
3DSRT
gender difference
資料タイプ
学位論文
抄録
Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
67
3-4
開始ページ
321
終了ページ
327
並び順
321
発行日
2020-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Maki Otomoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3433号
学位記番号
甲医第1463号
学位授与年月日
2020-09-10
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系