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ID 118744
タイトル別表記
十二指腸空腸バイパスの糖尿病に対する術後早期における効果
著者
沖川, 昌平 徳島大学大学院医学研究科(医学専攻)
キーワード
Duodenal-jejunal bypass (DJB)
Type2 diabetes mellitus (T2DM)
Glucose transporter 1 (GLUT1)
sodium-glucose cotransporter 1 (SGLT1)
Goto-kakizaki rat
資料タイプ
学位論文
抄録
Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
13
開始ページ
1856
発行日
2023-02-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Shohei Okikawaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3763号
学位記番号
甲医第1588号
学位授与年月日
2023-10-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系