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ID 106376
タイトル別表記
関心領域自動設定システムを用いた磁気共鳴動脈タギング撮像法と単一光子放射断層撮影における脳灌流定量画像の比較
Comparison of CBF between pCASL and SPECT
著者
岩永, 崇 徳島大学大学院保健科学教育部(保健学専攻)
久保, 均 The University of Tokushima KAKEN研究者をさがす
Funakoshi, Yasuhiro The University of Tokushima
Kunikane, Yamato Tokushima University
Matsuda, Tsuyoshi GE Healthcare Japan Corporation
キーワード
arterial spin labeling
iodine-123-N-isopropyl-p-iodoamphetamine
pulsed continuous arterial spin labeling
regional cerebral blood flow
3-dimensional stereotactic region-of-interest software
資料タイプ
学位論文
抄録
Purpose: We compared the regional cerebral blood flow (rCBF) obtained by pulsed continuous arterial spin labeling (pCASL) and iodine-123-N-isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) using 3-dimensional stereotactic region-of-interest (ROI) software for automated definition of ROIs in anatomic regions of the brain.
Methods: Thirteen patients with cerebrovascular occlusive disease and three with transient ischemic attacks underwent pCASL and IMP SPECT imaging. We compared rCBF values of each anatomic region and calculated the correlation coefficients between pCASL and IMP SPECT. We also calculated the asymmetry index (AI) using ROIs in contralateral regions of the hemispheres.
Results: The rCBF values calculated from pCASL and IMP SPECT were comparable in most segments, but rCBF in the thalamus (P < 0.0001) and hippocampus (P = 0.0006) was significantly higher measured by pCASL than IMP SPECT. The correlation of rCBF between pCASL and IMP SPECT in the affected hemisphere (r = 0.50) tended to be lower than that in the normal hemisphere (r = 0.59), but not significantly different (P = 0.25). Moreover, there was a fixed bias for underestimation of rCBF by pCASL (P = 0.0047) in the affected hemisphere. The calculated AI showed a significant relationship between methods (r = 0.79, P < 0.0001).
Conclusion: The rCBF obtained by pCASL had positive relationships with IMP SPECT. However, it should be considered that pCASL tends to have a weak relationship with IMP SPECT in some normal regions and regions affected by cerebrovascular occlusive disease.
掲載誌名
Magnetic Resonance in Medical Sciences
ISSN
18802206
13473182
cat書誌ID
AA12036292
AA11648770
出版者
Japanese Society for Magnetic Resonance in Medicine
13
4
開始ページ
239
終了ページ
249
発行日
2014-12-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201502041001.pdf
審査要旨 : LID201502041002.pdf
論文本文 : LID201502041003.pdf
本論文は, 著者Takashi IWANAGAの学位論文として提出され, 学位審査・授与の対象となっている。
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2781号
学位記番号
甲保第10号
学位授与年月日
2014-11-20
学位名
博士(保健学)
学位授与機関
徳島大学
部局
医学系