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ID 109893
タイトルヨミ
ヒト ノ ケンコウ ホジ ニオケル チョウナイキン ノ ヤクワリ
タイトル別表記
Intestinal microbiota and its role in human health
著者
片岡, 佳子 徳島大学大学院ヘルスバイオサイエンス研究部微生物・遺伝子解析学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
intestinal microbiota
ulcerative colitis
prebiotics
Bacteroides
organic acid
資料タイプ
学術雑誌論文
抄録
The healthy gut environment is complicated and controlled by the balance of intestinal immune system, intestinal microbiota, and microbial metabolites produced by intestinal bacteria. Imbalance of these elements in genetically susceptible persons has been known to promote inflammatory bowel disease and some lifestyle-related illnesses. Manipulation of intestinal microbiota with prebiotics, which can selectively stimulate a growth of beneficial bacteria, might contribute to keep healthy condition and to improve patient’s condition. I present some results of prebiotic effects in animal model and placebo-controlled, crossover study in healthy adults and patients with ulcerative colitis (UC). Through the clinical study, we found that UC patients had differences in microbiota composition and microbial metabolites. Decrease of Dominant anaerobic bacteria Bacteroides and diversity of microbiota composition was observed in UC. Amount of organic acids produced by bacterial fermentation reflectively decreased. Update on correlation of intestinal bacteria with human health and disease are reviewed.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
70
5-6
開始ページ
139
終了ページ
148
並び順
139
発行日
2014-12-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系