後肢非荷重による筋萎縮からの回復過程に及ぼすDHEA投与の効果

The purpose of this study was to test the hypothesis that dehydroepiandrosterone (DHEA)
accelerate recovery from hind-limb suspension
-induced skeletal muscle atrophy in rats by relieving oxidative stress. Male
Wistar-strain rats aged 6 weeks were allocated either to the control group or
the hind-limb suspended group. Some rats of the suspended group were
sacrificed at the end of the suspension of 10 day long. Some other rats of the
suspended group were suspended and the allowed to recover for 5 days with
DHEA，25mg/kg/day or without DHEA. The rats of the control group were
sacrificed at either time points when the suspended rats were sacrificed. For
all rats， muscle mass， muscle protein concentration and content were
measured. Oxidative stress and anti-oxidative capacity of the serum and
skeletal muscles were also evaluated.
In the soleus muscle，DHEA did not accelerate the recovery of the muscle
mass from the suspension-induced atrophy， although it improved
anti-oxidative capacity. In the medial gastrocnemius muscle， DHEA
promoted the muscle mass recovery without altering a redox status of the
muscle. These results indicate that muscle mass recovery from
suspension-induced atrophy does not depend on redox status of the skeletal
muscle.