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ID 116044
タイトル別表記
A case of the gastric metastasis from invasive lobular carcinoma of the breast
著者
三木, 仁司 田岡病院
開野, 友佳理 田岡病院
沖津, 奈都 田岡病院
山崎, 眞一 田岡病院
田中, 隆 田岡病院
キーワード
invasive lobular carcinoma
gastric metastasis
CK20
GCDFP-15
資料タイプ
学術雑誌論文
抄録
A 45-year-old woman underwent total mastectomy with axillary lymph node dissection for right breast cancer in 2015. Histopathological examination of the resected specimen showed triple-negative invasive lobular carcinoma and advanced lymph node metastasis. The patient underwent postoperative adjuvant therapy consisting of a dose-dense epirubicin-cyclophosphamide regimen and weekly paclitaxel and radiotherapy. However, multiple bone metastases were detected, 18 months postoperatively. The patient developed upper abdominal discomfort, 21 months postoperatively, and gastroscopy revealed multiple, irregular depressed lesions in the stomach. Histopathological examination of stomach biopsy specimens revealed tumor cells that showed diffuse invasion of the lamina propria of mucous membrane. Immunohistochemical evaluation of biopsy specimens obtained from the stomach and the excised breast tissue showed cells that were immunopositive for CK7 and GCDFP-15 and immunonegative for CK20. The gastric lesion was therefore diagnosed as metastases from invasive lobular carcinoma of the breast. Although the patient received chemotherapy, she died of meningeal carcinomatosis from breast cancer, 7 month after the diagnosis of stomach metastasis.
Immunohistochemical evaluation for CK20, which is expressed in gastric cancer and GCDFP-15, which originates from breast tissue, is useful to distinguish between breast cancer metastases and signet ring cell carcinoma of the stomach.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
77
1-2
開始ページ
87
終了ページ
90
並び順
87
発行日
2021-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系