古川, 貴大 徳島大学大学院医科学教育部（医学専攻）
Fujita, Koji Tokushima University
Shimizu, Fumitaka Yamaguchi University
Miyamoto, Katsuichi Kinki University
Takahashi, Yukitoshi Shizuoka Institute of Epilepsy and Neurological Disorders
Kanda, Takashi Yamaguchi University
Kusunoki, Susumu Kinki University
Amyotrophic lateral sclerosis
progressive muscular atrophy
multifocal motor neuropathy
Objective: We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) with those of patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) to investigate immunologic differences in the CNS.
Methods: CSF from 12 patients with MMN, 8 with PMA, 26 with sporadic ALS, and 10 with other noninflammatory neurologic disorders was analyzed for 27 cytokines and chemokines using the multiplex bead array assay. Cytokine titers of the 4 groups were compared, and correlations between the titers of relevant cytokines and clinical parameters were evaluated.
Results: There were no obvious intrathecal changes except for interleukin (IL)-1 receptor antagonist in patients with MMN. In contrast, IL-4, IL-7, IL-17, eotaxin/CCL11, fibroblast growth factor- 2 (FGF-2), granulocyte colony-stimulating factor (G-CSF), and platelet-derived growth factor BB titers were significantly elevated in patients with PMA and ALS; of these, FGF-2 and G-CSF titers were elevated compared with those in patients with MMN. IL-4 and IL-10 titers were high in patients with ALS, particularly patients with possible ALS presenting with a slowly progressive course or mild symptoms.
Conclusions: The CSF cytokine profile of patients with MMN is distinct from that of patients with PMA and ALS. The similarity of the cytokine profiles between patients with PMA and ALS suggests that PMA shares common immunologic features with ALS in the CNS, even without clinical evidence of upper motor neuron involvement.
Neurology : Neuroimmunology & Neuroinflammation
American Academy of Neurology|Wolters Kluwer Health
本論文は, 著者Takahiro Furukawaの学位論文として提出され, 学位審査・授与の対象となっている。
Copyright: © 2015 American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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