T1DM complication in continuous insulin
Masuda, Takafumi Osaka University
Katakami, Naoto Osaka University
Taya, Naohiro Osaka University
Miyashita, Kazuyuki Osaka University
Takahara, Mitsuyoshi Osaka University
Kato, Ken NHO Osaka National Hospital
Shimomura, Iichiro Osaka University
Continuous subcutaneous insulin infusion
Type 1 diabetes mellitus
To evaluate whether continuous subcutaneous insulin infusion attenuates the progression of diabetic complications, we retrospectively extracted data from 35 individuals who had developed type 1 diabetes mellitus aged ≤20 years and whose treatment had been changed from multiple daily injections to continuous subcutaneous insulin infusion. The annual changes in estimated glomerular filtration rate, urinary albumin excretion rate, carotid intima-media thickness and brachial-ankle pulse wave velocity during each treatment period were calculated. Although mean glycated hemoglobin under the continuous subcutaneous insulin infusion treatment was lower than that under the multiple daily injection treatment, there were no significant differences in annual changes in diabetic nephropathy and atherosclerosis between the two treatment periods. This pilot study showed that, in Japanese patients with juvenile-onset type 1 diabetes mellitus, there was no significant difference in the progression of diabetic nephropathy and atherosclerosis, at least in the early stage, between the two treatments.
Journal of Diabetes Investigation
Asian Association for the Study of Diabetes|John Wiley & Sons
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