西田, 憲生 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
桑野, 由紀 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
西川, 達哉 Tokushima University
増田, 清士 Tokushima University KAKEN研究者をさがす
六反, 一仁 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
DNA damage response
Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites have been shown to be direct players in the prevention or repair of DNA damage. In addition, non-coding RNAs, themselves, are involved in the RNA-mediated DNA repair system. Furthermore, RNA modification such as m6A methylation might also contribute to the ultraviolet-responsive DNA damage response. Accumulating evidence suggests that RNA metabolism is more deeply involved in diverse cellular functions than previously expected, and is also intricately associated with the maintenance of genome integrity. In this review, we highlight the roles of RBPs in the maintenance of genome integrity.
International Journal of Molecular Sciences
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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