ID | 118862 |
著者 |
Jargalsaikhan, Orgil
Tokushima University
Cai, Qinyi
Tokushima University
Miyakami, Yuko
Tokushima University
Atsumi, Kengo
Tokushima University
Tomita, Mitsuru
Tokushima University
Sutoh, Mitsuko
Institute for Animal Reproduction
Toyohara, Shunji
Institute for Animal Reproduction
Hokao, Ryoji
Institute for Animal Reproduction
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キーワード | glutamine synthetase
liver fatty acid-binding protein
serum amyloid A
beta-catenin
malignant transformation
focal nodular hyperplasia
immunostaining
diabetes
hyperlipidemia
HCA-like tumor
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資料タイプ |
学術雑誌論文
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抄録 | Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of hepatocellular carcinoma. In contrast, approximately 30% are GS-negative without prominent nuclear or structural atypia. In this study, we examined the characteristics of the GS-negative tumors of TSOD mice. Twenty male TSOD mice were sacrificed at 40 weeks and a total of 21 tumors were analyzed by HE staining and immunostaining of GS, liver fatty acid-binding protein (L FABP), serum amyloid A (SAA), and beta-catenin. With immunostaining for GS, six (29%) tumors were negative. Based on the histological and immunohistological characteristics, six GS-negative tumors were classified into several subtypes of human hepatocellular adenoma (HCA). One large tumor showed generally similar findings to inflammatory HCA, but contained small atypical foci with GS staining and partial nuclear beta-catenin expression suggesting malignant transformation. GS-negative tumors of TSOD mice contained features similar to various subtypes of HCA. Different HCA subtypes occurring in the same liver have been reported in humans; however, the diversity of patient backgrounds limits the ability to conduct a detailed, multifaceted analysis. TSOD mice may share similar mechanisms of HCA development as in humans. It is timely to review the pathogenesis of HCA from both genetic and environmental perspectives, and it is expected that TSOD mice will make further contributions in this regard.
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掲載誌名 |
International Journal of Molecular Sciences
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ISSN | 14220067
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出版者 | MDPI
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巻 | 23
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号 | 19
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開始ページ | 11923
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発行日 | 2022-10-07
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
歯学系
病院
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