アクセス数 : ?
ダウンロード数 : ?
ID 114469
タイトル別表記
Lymph Node Stromal Cell Subsets
著者
Takeuchi, Arata Niigata University
Ozawa, Madoka Niigata University
Kanda, Yasuhiro Niigata University
Kozai, Mina University of Tokushima
Kurosawa, Yoichi Niigata University
Rahman, Md Azizur Niigata University
Kawamura, Toshihiko Niigata University|Kitasato University
Shichida, Yuto Niigata University
Umemoto, Eiji Osaka University
Miyasaka, Masayuki University of Turku|Osaka University
Ludewig, Burkhard Kantonal Hospital St. Gallen
高浜, 洋介 University of Tokushima|National Institutes of Health 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Nagasawa, Takashi Osaka University
Katakai, Tomoya Niigata University
キーワード
chemokines
deep cortex
fibroblastic stromal cells
lymph node
medulla
subcompartment
資料タイプ
学術雑誌論文
抄録
The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRb, CCL21-ser, and CXCL12. Herein, we identified a unique FSC subset expressing both CCL21-ser and CXCL12 in the deep cortex periphery (DCP) that is characterized by preferential B cell localization. This subset was clearly different fromCXCL12highLepRhigh FSCs in themedullary cord, which harbors plasma cells. B cell localization in the DCP was controlled chiefly by CCL21-ser and, to a lesser extent, CXCL12. Moreover, the optimal development of the DCP as well as medulla requires B cells. Together, our findings suggest the presence of a unique microenvironment in the cortex-medulla boundary and offer an advanced view of the multi-layered stromal framework constructed by distinct FSC subsets in the LN.
掲載誌名
Frontiers in Immunology
ISSN
16643224
出版者
Frontiers Media S.A.
9
開始ページ
2196
発行日
2018-10-02
権利情報
Copyright © 2018 Takeuchi, Ozawa, Kanda, Kozai, Ohigashi, Kurosawa, Rahman, Kawamura, Shichida, Umemoto, Miyasaka, Ludewig, Takahama, Nagasawa and Katakai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/) The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所