ID | 118456 |
著者 |
Ganbaatar, Byambasuren
Tokushima University
Pham, Phuong Tran
Tokushima University
Aini, Kunduziayi
Tokushima University
Rahadian, Arief
Tokushima University
|
キーワード | Atherosclerosis
Inflammation
Macrophage
Olive polyphenol
Hydroxytyrosol
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資料タイプ |
学術雑誌論文
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抄録 | Background and Aims
The Mediterranean diet, which is characterized by high consumption of olive oil, prevents cardiovascular disease. Meanwhile, olive mill wastewater (OMWW), which is obtained as a byproduct during olive oil production, contains various promising bioactive components such as water-soluble polyphenols. Hydroxytyrosol (HT), the major polyphenol in OMWW, has anti-oxidative and anti-inflammatory properties; however, the atheroprotective effects of OMWW and HT remain to be fully understood. Here, we investigated the effect of OMWW and HT on atherogenesis. Methods and Results Male 8-week-old apolipoprotein E-deficient mice were fed a western-type diet supplemented with OMWW (0.30%w/w) or HT (0.02%w/w) for 20 weeks. The control group was fed a non-supplemented diet. OMWW and HT attenuated the development of atherosclerosis in the aortic arch as determined by Sudan IV staining (P<0.01, respectively) without alteration of body weight, plasma lipid levels, and blood pressure. OMWW and HT also decreased the production of oxidative stress (P<0.01, respectively) and the expression of NADPH oxidase subunits (e.g., NOX2 and p22phox) and inflammatory molecules (e.g., IL-1β and MCP-1) in the aorta. The results of in vitro experiments demonstrated that HT inhibited the expression of these molecules that were stimulated with LPS in RAW264.7 cells, murine macrophage-like cells. Conclusion OMWW and HT similarly attenuated atherogenesis. HT is a major component of water-soluble polyphenols in OMWW, and it inhibited inflammatory activation of macrophages. Therefore, our results suggest that the atheroprotective effects of OMWW are at least partially attributable to the anti-inflammatory effects of HT. |
掲載誌名 |
Heart and Vessels
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ISSN | 09108327
16152573
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cat書誌ID | AA10452161
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出版者 | Springer Nature Japan
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巻 | 38
|
号 | 11
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開始ページ | 1386
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終了ページ | 1394
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発行日 | 2023-07-18
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備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Natureʼs AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00380-023-02290-5
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言語 |
eng
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著者版フラグ |
著者版
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部局 |
病院
医学系
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