| ID | 111908 |
| 著者 |
Yamamoto, Jun
The University of Tokushima
Maeda, Nami
The University of Tokushima
Komiya, Chiaki
The University of Tokushima
Tanaka, Tomohiro
Tokyo Medical and Dental University
Ebisuno, Koji
The University of Tokushima
Nomura, Wataru
Tokyo Medical and Dental University
Tamamura, Hirokazu
Tokyo Medical and Dental University
|
| キーワード | Cleavable linker
Fluoride-responsive
Traceable linker
Stimulus-responsive amino acid
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules.
|
| 掲載誌名 |
Tetrahedron
|
| ISSN | 00404020
|
| cat書誌ID | AA00861787
AA11539786
|
| 出版者 | Elsevier Ltd.
|
| 巻 | 70
|
| 号 | 34
|
| 開始ページ | 5122
|
| 終了ページ | 5127
|
| 発行日 | 2014-06-06
|
| 権利情報 | © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
著者版
|
| 部局 |
薬学系
|
