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ID 116141
タイトル別表記
ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する
著者
Hirabayashi, Yuwa Tokushima University
Anzaki, Chieri Tokushima University
キーワード
experimental autoimmune encephalomyelitis
nobiletin
polymethoxyflavonoid
Th17 differentiation
IL-17A
polymethoxyflavone
資料タイプ
学位論文
抄録
Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Admin­istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
69
2
開始ページ
145
終了ページ
150
発行日
2021-09-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Akiko Nakamotoの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
乙第2117号
学位記番号
乙栄第96号
学位授与年月日
2021-07-29
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系