アクセス数 : ?
ダウンロード数 : ?
ID 115053
著者
髙濵, 充寛 Tokushima University|Osaka University
Fukuda, Mitsunori Tohoku University
Ohbayashi, Norihiko Tohoku University|University of Tsukuba
Kozaki, Tatsuya Tokushima University|Osaka University
Misawa, Takuma Osaka University
Okamoto, Toru Osaka University
Matsuura, Yoshiharu Osaka University
Akira, Shizuo Osaka University
齊藤, 達哉 Tokushima University|Osaka University KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase, RAB2B, and its effector protein, Golgi-associated RAB2B interactor-like 5 (GARIL5), in the cGAS-mediated IFN response. RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B deficiency enhances replication of vaccinia virus, a DNA virus. After DNA stimulation, RAB2B colocalizes with stimulator of interferon genes (STING), the downstream signal mediator of cGAS, on the Golgi apparatus. The GTP-binding activity of RAB2B is required for its localization on the Golgi apparatus and for recruitment of GARIL5. GARIL5 deficiency also affects the IFN response induced by cytosolic DNA and enhances replication of vaccinia virus. These findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis.
掲載誌名
Cell Reports
ISSN
22111247
出版者
Elsevier
20
12
開始ページ
2944
終了ページ
2954
発行日
2017-09-19
権利情報
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所