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ID 29066
著者
武田, 憲昭 Department of Otolaryngology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
モリタ, マサヒロ Department of Otolaryngology, Osaka University Medical School
ホリイ, アラタ Department of Otolaryngology, Osaka University Medical School
ニシイケ, スエタカ Department of Otolaryngology, Osaka University Medical School
キタハラ, タダシ Department of Otolaryngology, Osaka University Medical School
ウノ, アツヒコ Department of Otolaryngology, Osaka University Medical School
キーワード
motion sickness
space motion sickness
histamine
antihismamine
acetylcholine
scopolamine
noradrenaline
amphetamine
資料タイプ
学術雑誌論文
抄録
Three kinds of neurotransmitters : histamine, acetylcholine and noradrenaline, play important roles in the neural processes of motion sickness, because antihistamines, scopolamine and amphetamine are effective in preventing motion sickness. Histamine H1-receptors are involved in the development of the symptoms and signs of motion sickness, including emesis. On provocative motion stimuli, a neural mismatch signal activates the histaminergic neuron system in the hypothalamus, and the histaminergic descending impulse stimulates H1-receptors in the emetic center of the brainstem. The histaminergic input to the emetic center through H1-receptors is independent of dopamine D2-receptors in the chemoreceptor trigger zone in the area postrema and serotonin 5HT3-receptors in the visceral afferent, which are also involved in the emetic reflex. Antihistamines block emetic H1-receptors to prevent motion sickness. Scopolamine prevents motion sickness by modifying the neural store to reduce the neural mismatch signal and by facilitating the adaptation/habituation processes. The noradrenergic neuron system in the locus coeruleus is suppressed by the neural mismatch signal. Amphetamine antagonizes mismatch-induced suppression of noradrenergic neural transmission, resulting in preventing motion sickness.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
1-2
開始ページ
44
終了ページ
59
並び順
44
発行日
2001
備考
EDB ID
フルテキストファイル
言語
eng
部局
医学系