アクセス数 : ?
ダウンロード数 : ?
ID 109711
タイトル別表記
食餌性リン負荷がラットにおける鉄欠乏性貧血の発症・進展と鉄代謝に及ぼす影響
著者
中尾, 真理 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
山本, 浩範 University of Tokushima|Jin-ai University|University of Fukui KAKEN研究者をさがす
Nakahashi, Otoki University of Tokushima
Ikeda, Shoko University of Tokushima
Abe, Kotaro University of Tokushima
Ishiguro, Mariko Jin-ai University
Iwano, Masayuki University of Fukui
キーワード
Anemia
Dietary phosphate
Gene expression
iron-deficient
Rat
資料タイプ
学位論文
抄録
Inorganic phosphate (Pi) plays critical roles in bone metabolism and is an essential component of 2,3-diphosphoglycerate (2,3-DPG). It has been reported that animals fed a low-iron diet modulate Pi metabolism, whereas the effect of dietary Pi on iron metabolism, particularly in iron deficiency anemia (IDA), is not fully understood. In this study, we hypothesized the presence of a link between Pi and iron metabolism and tested the hypothesis by investigating the effects of dietary Pi on iron status and IDA. Wistar rats aged 4 weeks were randomly assigned to 1 of 4 experimental dietary groups: normal iron content (Con Fe) + 0.5% Pi, low-iron (Low Fe) + 0.5% Pi, Con Fe + 1.5% Pi, and Low Fe + 1.5% Pi. Rats fed the 1.5% Pi diet for 14 days, but not for 28 days, maintained their anemia state and plasma erythropoietin concentrations within the reference range, even under conditions of low iron. In addition, plasma concentrations of 2,3-DPG were significantly increased by the 1.5% Pi diets and were positively correlated with plasma Pi concentration (r = 0.779; P < .001). Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin. Furthermore, iron concentration in liver tissues was increased by the 1.5% Pi in Con Fe diet. These results suggest that dietary Pi supplementation delays the onset of IDA and increases plasma 2,3- DPG concentration, followed by modulation of the expression of iron-regulated genes.
掲載誌名
Nutrition Research
ISSN
02715317
cat書誌ID
AA10621327
AA11535322
出版者
Elsevier
35
11
開始ページ
1016
終了ページ
1024
発行日
2015-09-03
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606151005.pdf
論文本文 : LID201612081001.pdf
著者の申請により要約(2016-06-15公開)に替えて論文本文を公開(2016-12-08)
本論文は, 著者Mari Nakaoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2947号
学位記番号
甲栄第235号
学位授与年月日
2016-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系