直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 117188
著者
Wang, Yinli Tokushima University|Kyoto University
Yamauchi, Akiho Tokushima University
Hashimoto, Keiji Tokushima University
Fujiwara, Tatsuya Tokushima University
Mitani, Yuta Tokushima University
Kuwano, Satoru Kyoto University
Yamaoka, Yousuke Kyoto University
Takasu, Kiyosei Kyoto University
キーワード
organocatalysis
molecular recognition
catalytic kinetic resolution
α-hydroxythioamide
N-heterocyclic carbene
資料タイプ
学術雑誌論文
抄録
We describe a way of understanding enhanced molecular recognition through substrate–additive complex formation, and the development of the catalytic kinetic resolution of α-hydroxythioamides, which are versatile synthetic building blocks, using chiral N-heterocyclic carbine-catalyzed enantioselective acylation assisted by a carboxylate additive. Mass spectrometry provided evidence for the role of the additive, which forms a hydrogen-bonded complex with α-hydroxythioamide, resulting in both rate and selectivity enhancements. The synthetic applications of the resolved α-hydroxythioamides highlight the usefulness of the developed method.
掲載誌名
ACS Catalysis
ISSN
21555435
cat書誌ID
AA12599706
出版者
ACS Publications
12
10
開始ページ
6100
終了ページ
6107
発行日
2022-05-06
権利情報
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscatal.2c01579.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系
理工学系